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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
21.52
Human Site:
Y110
Identified Species:
39.44
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
Y110
L
Y
D
N
L
E
K
Y
H
L
P
Y
P
E
A
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
Y69
F
A
L
A
K
E
L
Y
P
G
Q
F
K
P
T
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
G97
L
A
K
E
L
Y
P
G
Q
F
K
P
T
V
C
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
Y110
L
Y
A
N
L
E
K
Y
H
L
P
Y
P
E
A
Rat
Rattus norvegicus
Q5RJQ4
350
39301
E100
P
F
F
A
L
A
K
E
L
Y
P
G
Q
F
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
Y124
L
Y
A
N
L
G
R
Y
E
L
P
Y
P
E
A
Frog
Xenopus laevis
NP_001088636
413
45548
Y138
L
Y
S
N
L
Q
K
Y
N
L
P
Y
P
E
A
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
Y108
L
Y
A
N
L
Q
K
Y
N
L
P
Y
P
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
L105
N
P
A
P
F
F
A
L
A
K
E
L
Y
P
G
Honey Bee
Apis mellifera
XP_393038
355
40940
H105
S
P
T
S
G
L
Y
H
N
L
E
K
Y
N
L
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
K143
A
D
A
V
E
L
F
K
T
K
K
H
I
L
V
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
Y107
L
Y
D
N
L
Q
K
Y
N
L
P
N
P
Q
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
K106
L
L
K
L
F
Q
D
K
D
V
L
K
R
V
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
13.3
N.A.
13.3
N.A.
93.3
20
N.A.
N.A.
73.3
80
80
N.A.
0
6.6
0
73.3
P-Site Similarity:
100
20
N.A.
13.3
N.A.
93.3
26.6
N.A.
N.A.
80
93.3
93.3
N.A.
0
26.6
6.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
16
39
16
0
8
8
0
8
0
0
0
0
0
47
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
8
16
0
0
0
8
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
8
8
24
0
8
8
0
16
0
0
39
0
% E
% Phe:
8
8
8
0
16
8
8
0
0
8
0
8
0
8
0
% F
% Gly:
0
0
0
0
8
8
0
8
0
8
0
8
0
0
8
% G
% His:
0
0
0
0
0
0
0
8
16
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
16
0
8
0
47
16
0
16
16
16
8
0
8
% K
% Leu:
62
8
8
8
62
16
8
8
8
54
8
8
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
47
0
0
0
0
31
0
0
8
0
8
0
% N
% Pro:
8
16
0
8
0
0
8
0
8
0
54
8
47
16
0
% P
% Gln:
0
0
0
0
0
31
0
0
8
0
8
0
8
8
0
% Q
% Arg:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% R
% Ser:
8
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
8
0
0
0
8
0
8
% T
% Val:
0
0
0
8
0
0
0
0
0
8
0
0
0
16
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
47
0
0
0
8
8
54
0
8
0
39
16
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _